MPK files are associated with Painkiller Overdose, a computer game developed by Mindware Studios. MPK files store maps used in the game, as well as terrain layout, objects, textures, and physics.

Painkiller Overdose is a FPP/FPS shooter game. It was released in 2007 for PC. The game offers a single-player campaign that spans sixteen levels and a multi-player mode. The game runs fairly well on low-end machines.