Files with the VDB extension are primarily associated with Norton Antivirus. It is software that protects the operating system against malware and viruses. The VDB file is used to store the virus definition database. During the period when the user has a valid subscription, such a file is automatically updated by the program. Before the virus database file is sent to the client, the VDB file is converted to XDB.

Norton Antivirus is one of the most popular tools of this type developed by Symantec Corporation.